ETF · holdings as filed 2026-03-31
What's inside XBI?
State Street(R) SPDR(R) S&P(R) Biotech ETF
- Holdings
- 155
- positions in the fund
- Top 10
- 19%
- of fund assets
- Expense ratio
- 0.35%
- net, per year
- Fund size
- $7B
- total net assets
Top 20 holdings
| Rank | Logo | Ticker / Name | Weight | |
|---|---|---|---|---|
| 1 | G  | GVMXXSTATE ST INST US GOV MM-PREM | 7.47% | |
| 2 | 1  | 1JKAPELLIS PHARMACEUTICALS INC | 1.70% | |
| 3 | A  | ALKSALKERMES PLC | 1.34% | |
| 4 | M  | MDGLMADRIGAL PHARMACEUTICALS INC | 1.28% | |
| 5 | T  | TGTXTG THERAPEUTICS INC | 1.25% | |
| 6 | I  | INSMINSMED INC | 1.24% | |
| 7 | S  | SRRKSCHOLAR ROCK HOLDING CORP | 1.20% | |
| 8 | A  | APGEAPOGEE THERAPEUTICS INC | 1.19% | |
| 9 | P  | PTGXPROTAGONIST THERAPEUTICS INC | 1.15% | |
| 10 | S  | SMMTSUMMIT THERAPEUTICS INC | 1.15% | |
| 11 | U  | UTHRUNITED THERAPEUTICS CORP | 1.15% | |
| 12 | P  | PRAXPRAXIS PRECISION MEDICINES I | 1.14% | |
| 13 | A  | ARWRARROWHEAD PHARMACEUTICALS IN | 1.14% | |
| 14 | C  | COGTCOGENT BIOSCIENCES INC | 1.13% | |
| 15 | B  | BBIOBRIDGEBIO PHARMA INC | 1.10% | |
| 16 | P  | PTCTPTC THERAPEUTICS INC | 1.09% | |
| 17 | C  | CYTKCYTOKINETICS INC | 1.09% | |
| 18 | A  | ALNYALNYLAM PHARMACEUTICALS INC | 1.09% | |
| 19 | E  | EXELEXELIXIS INC | 1.08% | |
| 20 | ? | —Nuvalent Inc | 1.08% |
Top holdings — Health Care
Your 10 largest positions in this sector
1
A
ALKSALKERMES PLC
1.34%2
M
MDGLMADRIGAL PHARMACEUTICALS INC
1.28%3
T
TGTXTG THERAPEUTICS INC
1.25%4
I
INSMINSMED INC
1.24%5
S
SRRKSCHOLAR ROCK HOLDING CORP
1.20%6
A
APGEAPOGEE THERAPEUTICS INC
1.19%7
P
PTGXPROTAGONIST THERAPEUTICS INC
1.15%8
S
SMMTSUMMIT THERAPEUTICS INC
1.15%9
U
UTHRUNITED THERAPEUTICS CORP
1.15%10
P
PRAXPRAXIS PRECISION MEDICINES I
1.14%Top holdings — United States
Your 10 largest positions in this country
1
G
GVMXXSTATE ST INST US GOV MM-PREM
7.47%2
M
MDGLMADRIGAL PHARMACEUTICALS INC
1.28%3
T
TGTXTG THERAPEUTICS INC
1.25%4
I
INSMINSMED INC
1.24%5
S
SRRKSCHOLAR ROCK HOLDING CORP
1.20%6
A
APGEAPOGEE THERAPEUTICS INC
1.19%7
P
PTGXPROTAGONIST THERAPEUTICS INC
1.15%8
S
SMMTSUMMIT THERAPEUTICS INC
1.15%9
U
UTHRUNITED THERAPEUTICS CORP
1.15%10
P
PRAXPRAXIS PRECISION MEDICINES I
1.14%Geography reflects each issuer's registered business address per SEC EDGAR filings where available, falling back to the exchange or listing where no SEC filing exists — not necessarily where a company's stock is primarily listed (e.g. TSMC is classified as Taiwan even though its ADR trades on the NYSE).
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Data source: official SEC Form N-PORT filings (as of 2026-03-31); expense ratio from SEC prospectus (risk/return) filings. Fund holdings are disclosed quarterly and may reflect a 60-day reporting delay.
Informational and educational only — not investment advice.
Informational and educational only — not investment advice.