ETF · holdings as filed 2026-06-30
What's inside XBI?
State Street(R) SPDR(R) S&P(R) Biotech ETF
- Holdings
- 158
- positions in the fund
- Top 10
- 17%
- of fund assets
- Expense ratio
- 0.35%
- net, per year
- Fund size
- $11B
- total net assets
Top 20 holdings
| Rank | Logo | Ticker / Name | Weight | |
|---|---|---|---|---|
| 1 | G  | GVMXXSTATE ST INST US GOV MM-PREM | 5.59% | |
| 2 | A  | APGEAPOGEE THERAPEUTICS INC | 1.41% | |
| 3 | M  | MRNAMODERNA INC | 1.33% | |
| 4 | T  | TWSTTWIST BIOSCIENCE CORP | 1.33% | |
| 5 | O  | ORKAORUKA THERAPEUTICS INC | 1.30% | |
| 6 | K  | KYMRKYMERA THERAPEUTICS INC | 1.28% | |
| 7 | V  | VKTXVIKING THERAPEUTICS INC | 1.23% | |
| 8 | P  | PRAXPRAXIS PRECISION MEDICINES I | 1.22% | |
| 9 | E  | ERASERASCA INC | 1.20% | |
| 10 | R  | RVMDREVOLUTION MEDICINES INC | 1.14% | |
| 11 | R  | RYTMRHYTHM PHARMACEUTICALS INC | 1.13% | |
| 12 | C  | CGONCG ONCOLOGY INC | 1.13% | |
| 13 | S  | SLSSELLAS LIFE SCIENCES GROUP I | 1.12% | |
| 14 | P  | PCVXVAXCYTE INC | 1.12% | |
| 15 | D  | DNTHDIANTHUS THERAPEUTICS INC | 1.12% | |
| 16 | C  | CYTKCYTOKINETICS INC | 1.11% | |
| 17 | N  | NTRANATERA INC | 1.10% | |
| 18 | S  | SRRKSCHOLAR ROCK HOLDING CORP | 1.09% | |
| 19 | R  | ROIVROIVANT SCIENCES LTD | 1.09% | |
| 20 | M  | MIRMMIRUM PHARMACEUTICALS INC | 1.09% |
Top holdings — Health Care
Your 10 largest positions in this sector
1
A
APGEAPOGEE THERAPEUTICS INC
1.41%2
M
MRNAMODERNA INC
1.33%3
T
TWSTTWIST BIOSCIENCE CORP
1.33%4
O
ORKAORUKA THERAPEUTICS INC
1.30%5
K
KYMRKYMERA THERAPEUTICS INC
1.28%6
V
VKTXVIKING THERAPEUTICS INC
1.23%7
P
PRAXPRAXIS PRECISION MEDICINES I
1.22%8
E
ERASERASCA INC
1.20%9
R
RVMDREVOLUTION MEDICINES INC
1.14%10
R
RYTMRHYTHM PHARMACEUTICALS INC
1.13%Top holdings — United States
Your 10 largest positions in this country
1
G
GVMXXSTATE ST INST US GOV MM-PREM
5.59%2
A
APGEAPOGEE THERAPEUTICS INC
1.41%3
M
MRNAMODERNA INC
1.33%4
T
TWSTTWIST BIOSCIENCE CORP
1.33%5
O
ORKAORUKA THERAPEUTICS INC
1.30%6
K
KYMRKYMERA THERAPEUTICS INC
1.28%7
V
VKTXVIKING THERAPEUTICS INC
1.23%8
P
PRAXPRAXIS PRECISION MEDICINES I
1.22%9
E
ERASERASCA INC
1.20%10
R
RVMDREVOLUTION MEDICINES INC
1.14%Geography reflects each issuer's registered business address per SEC EDGAR filings where available, falling back to the exchange or listing where no SEC filing exists — not necessarily where a company's stock is primarily listed (e.g. TSMC is classified as Taiwan even though its ADR trades on the NYSE).
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Data source: official SEC Form N-PORT filings (as of 2026-06-30); expense ratio from SEC prospectus (risk/return) filings. Fund holdings are disclosed quarterly and may reflect a 60-day reporting delay.
Informational and educational only — not investment advice.
Informational and educational only — not investment advice.